ea0063gp188 | Adrenal and Neuroendocrine - Clinical | ECE2019
Tresoldi Alberto S
, Sumilo Dana
, Perrins Mary
, Toulis Konstantinos A
, Prete Alessandro
, Reddy Narendra
, Wass John A
, Nirantharakumar Krishnarajah
, Arlt Wiebke
Background: Primary adrenal insufficiency (PAI) can be of autoimmune origin (Addisons disease, AD) or due to inborn disorders of steroidogenesis (congenital adrenal hyperplasia, CAH). Prognosis of patients with PAI has improved considerably after glucocorticoid replacement therapy became available. However, even in recent years, an increased risk of death has been described in both AD and CAH patients. Moreover, even with the current state-of-the-art replacement therapy,...